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Disruption of thyroxine transport by persistent organic pollutants in Inuit women of childbearing age from Nunavik

Metadata

File Identifier: 11044_iso.xml
Metadata Language: eng; CAN
: utf8
Resource Type: Dataset
Responsible Party: Individual Name: Polar Data Catalogue Organisation Name: Canadian Cryospheric Information Network Role: Point Of Contact Contact Info: Voice: (519) 888-4567 x32689 Street Address: 200 University Avenue West, University of Waterloo City: Waterloo Province/State: Ontario Postal Code/ZIP: N2L 3G1 Country: Canada E-Mail Address: pdc@uwaterloo.ca
Metadata Date: 2014-04-08
Metadata Standard Name: North American Profile of ISO 19115:2003
Metadata Standard Version: 2009-01-01

Data Identification

Abstract: Contaminants that are present in the Arctic aquatic food chain may alter brain development in Inuit infants. One possible mechanism involves interference with the thyroid system during the developmental stage by metabolites of persistent organic pollutants that resemble the endogenous hormone L-thyroxine (T4). The disruption of T4 transport has received special attention since some hydroxylated metabolites of polychlorinated biphenyls and polybrominated diphenyl ethers have been shown to bind to transthyretin (TTR), a transport protein involved in supplying the foetus with T4 and transporting T4 across the blood brain barrier to the developing brain. Recently, several other compounds have been identified as binders of TTR and thyroid binding globulin (TBG), another T4 transport that may be involved in supplying the placenta with T4. The objective of this study is to examine whether plasma levels of these compounds are linked to a decrease in the proportion of circulating T4 bound to TTR and/or TBG in Inuit women of childbearing age. Such a relation would strengthen the biological plausibility of a link between exposure to food chain contaminants and adverse effects on brain development in this population. Major compounds that displace T4 from its transport proteins will also be identified.
Purpose: The main objective of this study is to investigate relations between plasma concentrations of persistent organic pollutants (and their metabolites) and the amount of thyroid hormones bound to their transport proteins in Inuit women of childbearing age. The secondary objective is to identify the major chemicals other than thyroid hormones that are bound to these proteins.
Language: eng; CAN
Citation:
Contact Info: Title: Disruption of thyroxine transport by persistent organic pollutants in Inuit women of childbearing age from Nunavik Date: Date: 2014-04-08 Date Type: Publication Date Individual Name: Pierre Ayotte Role: Principal Investigator Individual Name: Pierre Ayotte Role:
Point Of Contact:
Individual Name: Polar Data Catalogue Organisation Name: Canadian Cryospheric Information Network Role: Point Of Contact Contact Info: Voice: (519) 888-4567 x32689 Street Address: 200 University Avenue West, University of Waterloo City: Waterloo Province/State: Ontario Postal Code/ZIP: N2L 3G1 Country: Canada E-Mail Address: pdc@uwaterloo.ca Online Resource: polardata.ca
Topic Category: Environment and Conservation
Keyword Collection:
Keyword: Brominated diphenyl ethers Keyword: Contaminants Keyword: Development Keyword: Food web Keyword: Inuit Health Survey Keyword: Inuit population Keyword: Nunavik Keyword: Persistent organic pollutants (POPs) Keyword: Pregnancy Associated Thesaurus: Polar Data Catalogue Thesaurus (Canada) Keyword: Nunavik, Quebec
Spatial Extent:
West Bounding Longitude: -64 East Bounding Longitude: -64 North Bounding Latitude: 55 South Bounding Latitude: 55
Legal Constraints:
Access Constraints: Other Restrictions Use Constraints: Other Restrictions Other Constraints: Terms of Use of the Polar Data Catalogue: https://www.polardata.ca/pdcinput/public/termsofuse

Distribution

Distribution Format:
Format Name: Digital file Format Version: 1.0
Distributor:
Distributor Contact: Individual Name: Polar Data Catalogue Organisation Name: Canadian Cryospheric Information Network Role: Distributor Contact Info: Voice: (519) 888-4567 x32689 Street Address: 200 University Avenue West, University of Waterloo City: Waterloo Province/State: Ontario Postal Code/ZIP: N2L 3G1 Country: Canada E-Mail Address: pdc@uwaterloo.ca

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